Studies on Actinomyces tumemacerans strain INMI P-42 with particular reference to antibiotic production.

A further characterization of Actinomyces tumemacerans Krassilnikov and Koveshnikov, 1962 strain INMI P-42 was carried out. It is classified in Section Monoverticillus-Spira, Series white to gray. When the organism was shakecultured in a wheat flour medium, an antibacterial antibiotic with limited antitumor activity was isolated from the culture filtrate and a tetraene antibiotic from the mycelial cake. The antibacterial antibiotic proved to be closely related to or identical with BA-180265 A (kanchanomycin) reported by Liu et at. in 1963.